Metabolic effects of antipsychotic drugs

Adipogenic and Metabolic Effects of Antipsychotic Drugs

Overview: Though possessing many advantages, many Antipsychotic drugs (APDs) have a major liability in their ability to promote adiposity, obesity, and metabolic dysregulation in an already metabolically vulnerable population. The past decade has witnessed substantial research effort aimed at quantifying, understanding, preventing, and alleviating these adverse effects and our goal is to provid...

Motor side effects of atypical antipsychotic drugs

There are two central issues to consider in assessing the motor side effects of atypical antipsychotic (AA) drugs. The fi rst is the defi nition of what it means to be an AA drug. While one review states that ‘the defi ning characteristic of an AA is its lower risk of inducing EPS [extra pyramidal symptoms] [1]’ there is, in fact, no consensus defi nition [2] of what it means to be ‘atypical’. ...

The metabolic effects of antipsychotic medications.

OBJECTIVES To review current evidence for the hypothesis that treatment with antipsychotic medications may be associated with increased risks for weight gain, insulin resistance, hyperglycemia, dyslipidemia, and type 2 diabetes mellitus (T2DM) and to examine the relation of adiposity to medical risk. METHODS We identified relevant publications through a search of MEDLINE from the years 1975 t...

Recent Advances in Understanding and Mitigating Adipogenic and Metabolic Effects of Antipsychotic Drugs

Although offering many benefits for several psychiatric disorders, antipsychotic drugs (APDs) as a class have a major liability in their tendency to promote adiposity, obesity, and metabolic dysregulation in an already metabolically vulnerable population. The past decade has witnessed substantial research aimed at investigating the mechanisms of these adverse effects and mitigating them. On Jul...

Antipsychotic drugs and metabolic syndrome--can we prevent it?